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The appearance of peripheral giant-cell granuloma is also similar to pyogenic granuloma. The color ranges from red to bluish-purple, but is usually more blue in comparison to pyogenic granuloma. It can be sessile or pedunculated with the size usually being less than 2 cm. The lesion has a 60% gender predilection to females. The prevalence of ...
High magnification micrograph of giant cells in a giant-cell tumor of bone, H&E stain. The diagnosis of giant-cell tumors is based on biopsy findings. The key histomorphologic feature is, as the name of the entity suggests, (multinucleated) giant cells with up to a hundred nuclei that have prominent nucleoli.
The giant cells may be diffusely located throughout the lesion or focally aggregate in the lesion, often clustered around hemorrhagic areas hemosiderin deposits. Lobules of the lesion can be separated by fibrous tissue or even thin layer of bone or osteoid that can be seen radiographically. Giant cells are thought to form in response to signals ...
A giant cell (also known as a multinucleated giant cell, or multinucleate giant cell) is a mass formed by the union of several distinct cells (usually histiocytes), often forming a granuloma. [ 1 ] Although there is typically a focus on the pathological aspects of multinucleate giant cells (MGCs), they also play many important physiological roles.
Tenosynovial giant cell tumor (TGCT) is a non-malignant tumor defined histologically as inclusions of “osteoclast-like” multinucleated giant cells, hemosiderin, and macrophages. [1] This histology can present one of 2 clinically distinct ways. TGCT tumors often develop from the lining of joints (also known as synovial tissue).
Due to its overwhelming incidence on the gingiva, the condition is often associated with two other diseases, though not because they occur together. Instead, the three are associated with each other because they appear frequently on gingiva—peripheral giant cell granuloma and peripheral ossifying fibroma. Detailed analysis can be used to ...
Annular elastolytic giant-cell granuloma (also known as "Giant cell elastophagocytosis," [1] "Meischer's granuloma," [2] "Miescher's granuloma of the face" [1]) is a cutaneous condition characterized histologically by a dermal infiltrate of macrophages.
Giant-cell fibromas are commonly located on the gingiva.The tongue is the second most common location, followed by the palate or buccal mucosa.Giant-cell fibromas are usually asymptomatic and appear as 0.5-1cm pedunculated or sessile lesions with a pebbly or bosselated surface.