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Other less common side effects included nausea, vomiting, diarrhea, dizziness, fatigue, and fever. [37] Pelvic inflammatory disease is a very rare but serious complication. [ 38 ] Excessive bleeding and incomplete termination of a pregnancy require further intervention by a doctor (such as a repeat dose of misoprostol or a vacuum aspiration ).
Antiglucocorticoid drugs are a class of medications that act to reduce the effects of glucocorticoids, primarily cortisol, in the body. [1] They include direct glucocorticoid receptor antagonists such as mifepristone and synthesis inhibitors such as metyrapone, ketoconazole, and aminoglutethimide. They are used to treat Cushing's syndrome. [2]
Docusate is the common chemical and pharmaceutical name of the anion bis(2-ethylhexyl) sulfosuccinate, also commonly called dioctyl sulfosuccinate (DOSS). [2] [3] [4]Salts of this anion, especially docusate sodium, are widely used in medicine as an emollient laxative and as stool softeners, by mouth or rectally. [1]
Water softening is the removal of calcium, magnesium, and certain other metal cations in hard water. The resulting soft water requires less soap for the same cleaning effort, as soap is not wasted bonding with calcium ions. Soft water also extends the lifetime of plumbing by reducing or eliminating scale build-up in pipes
Mifepristone (RU-486; Mifegyne, Mifeprex): An antiprogestogen which is widely used as an abortifacient. Also has antiglucocorticoid and AR antagonist activity. Has been found to produce gynecomastia as a side effect in men at a relatively high rate in clinical studies. Has been studied as a treatment for prostate cancer.
[157] [158] As of 2022, there is no scientifically rigorous evidence that the effects of mifepristone can be reversed this way. [ 159 ] [ 160 ] [ 161 ] Even so, several states in the US require providers of non-surgical abortion who use mifepristone to tell patients that reversal is an option. [ 162 ]
It was originally introduced into European markets during the 1990s due to concerns over the environmental effects of DODAC, which was the principle softener used at the time. [2] The main difference was the incorporation of cleavable ester groups intended to accelerate its biodegradation.
A drug or procedure usually used for a specific effect may be used specifically because of a beneficial side-effect; this is termed "off-label use" until such use is approved. [1] For instance, X-rays have long been used as an imaging technique ; the discovery of their oncolytic capability led to their use in radiotherapy for ablation of ...
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