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Arsphenamine, also known as Salvarsan or compound 606, is an antibiotic drug that was introduced at the beginning of the 1910s as the first effective treatment for the deadly infectious diseases syphilis, relapsing fever, and African trypanosomiasis. [2] [3] This organoarsenic compound was the first modern antimicrobial agent. [4]
Salvarsan required improvement as to side effects and solubility and was replaced in 1911 with Neosalvarsan. Ehrlich's work illuminated the existence of the blood-brain barrier, although he himself never believed in such a barrier, with Lina Stern later coining the phrase. The medication triggered the so-called "Salvarsan war".
As faith in the new cure starts to dwindle, Ehrlich is forced to sue Wolfert for libel and in the process exonerate 606. Dr. von Behring (who had earlier told Ehrlich to give up his pipe dreams of cures by chemicals), is called by the defense to denounce 606. Behring instead states that he believes that 606 is responsible for a 39th death: the ...
When Hata injected compound 606, arsphenamine, into rabbits infected with syphilis, he found it to be effective against syphilis in vivo. [2] [6] It was called compound 606 because it was the 606th compound that Ehrlich and Hata tested. Arsphenamine was first thought to be ineffective when it was tested by Ehrlich's former assistants, so their ...
1911 – Arsphenamine, also Salvarsan [1] 1912 – Neosalvarsan; 1935 – Prontosil (an oral precursor to sulfanilamide), the first sulfonamide; 1936 – Sulfanilamide; 1938 – Sulfapyridine (M&B 693) 1939 – sulfacetamide; 1940 – sulfamethizole; 1942 – benzylpenicillin, the first penicillin; 1942 – gramicidin S, the first peptide ...
Both Salvarsan and Neosalvarsan were developed in the laboratory of Paul Ehrlich in Frankfurt, Germany. Their discoveries were the result of the first organized team effort to optimize the biological activity of a lead compound through systematic chemical modifications. [1] This scheme is the basis for most modern pharmaceutical research.
More than 800 people have lost their lives in jail since July 13, 2015 but few details are publicly released. Huffington Post is compiling a database of every person who died until July 13, 2016 to shed light on how they passed.
The first effective treatment, Salvarsan, was developed in 1910 by Sahachiro Hata in the laboratory of Paul Ehrlich. It was followed by the introduction of penicillin in 1943. [2] Many well-known figures, including Scott Joplin, Franz Schubert, Friedrich Nietzsche, Al Capone, and Édouard Manet are believed to have contracted the disease. [2]