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Temazepam, sold under the brand name Restoril among others, is a medication of the benzodiazepine class which is generally used to treat severe or debilitating insomnia. [8] It is taken by mouth. [8] Temazepam is rapidly absorbed, and significant hypnotic and anxiolytic effects begin in less than 30 minutes and can last for up to eight hours.
"Time to peak" refers to when maximum levels of the drug in the blood occur after a given dose. Benzodiazepines generally share the same pharmacological properties, such as anxiolytic, sedative, hypnotic, skeletal muscle relaxant, amnesic, and anticonvulsant effects. Variation in potency of certain effects may exist amongst individual ...
A few drugs such as alcohol are absorbed by the lining of the stomach, and therefore tend to take effect much more quickly than the vast majority of oral medications which are absorbed in the small intestine. Gastric emptying time can vary from 0 to 3 hours, [2] and therefore plays a major role in onset of action for orally administered drugs ...
Non-medical temazepam use reached epidemic proportions in some parts of the world, in particular, in Europe and Australia, and is a major addictive substance in many Southeast Asian countries. This led authorities of various countries to place temazepam under a more restrictive legal status.
Comparison to oral morphine [a] Analgesic Strength (relative) Equivalent dose (10 mg oral morphine) [b] Bioavailability Half-life of active metabolites (hours) Oral-to-parenteral ratio Speed of onset Duration Paracetamol (non-opioid) 1 ⁄ 360: 3600 mg 63–89% 1–4 37 min ; 8 min 5–6 hours Aspirin (NSAID, non-opioid) 1 ⁄ 360: 3600 mg 80 ...
In a comparison study, a rapid taper using benzodiazepines was found to be superior to a phenobarbital rapid taper. [106] [107] Pregabalin may help reduce the severity of benzodiazepine withdrawal symptoms, [108] and reduce the risk of relapse. [109] Propranolol was not found to increase the discontinuation success rate. [86]
During this time, a total of 52% of drug forgeries were for benzodiazepines, suggesting they were a major prescription drug class of abuse. [ 40 ] However, due to its slow rate of absorption and its slow onset of action, [ 30 ] oxazepam has a relatively low potential for abuse compared to some other benzodiazepines, such as temazepam ...
Flurazepam is a long-acting benzodiazepine and is sometimes used in patients who have difficulty in maintaining sleep, though benzodiazepines with intermediate half-lives such as loprazolam, lormetazepam, and temazepam are also indicated for patients with difficulty maintaining sleep.