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Her bone mass was lower than expected for her age, and levels of osteocalcin and C-terminal telopeptide were both elevated, suggesting an increased rate of bone turnover. [9] She was 162.6 cm tall, and her growth velocity indicated a lack of estrogen-induced growth spurt at puberty. [ 9 ]
The symptoms of hypogonadotrophic hypogonadism, a subtype of hypogonadism, include late, incomplete, or lack of development at puberty, and sometimes short stature or the inability to smell; in females, a lack of breasts and menstrual periods, and in males a lack of sexual development, e.g., facial hair, penis, and testes enlargement, deepening ...
XY complete gonadal dysgenesis, also known as Swyer syndrome, is a type of defect hypogonadism in a person whose karyotype is 46,XY. Though they typically have normal vulvas, [1] the person has underdeveloped gonads, fibrous tissue termed "streak gonads", and if left untreated, will not experience puberty.
In the United States, the age of onset of puberty in girls depends heavily on their racial background. Delayed puberty means the lack of breast development by age 12.8 years for White girls, and by age 12.4 years for Black girls. [7] [8] The lack of menstruation by age 15 in any ethnic background is considered delayed. [8]
The lack of menstruation usually begins shortly after beginning the medication and can take up to a year to resume after stopping its use. [41] Hormonal contraceptives that contain only progestogen, like the oral contraceptive Micronor, and especially higher-dose formulations, such as the injectable Depo-Provera , commonly induce this side effect .
Outside of the reproductive years there is absence of menses during childhood and after menopause. [8] Irregular menstruation is where there is variation in menstrual cycle length of more than approximately 8 days for a woman. The term metrorrhagia is often used for irregular menstruation that occurs between the expected menstrual periods. [9] [10]
[4] [9] However, studies have shown that even during this period, the length of a menstrual cycle does not exceed 45 days. [4] [9] Furthermore, healthy girls with normal BMI (18.5–24.9 kg/m 2) should develop regular menstrual cycles (every 28 +/- 3–5 days) within 1–2 years after menarche.
Müllerian agenesis, also known as Müllerian aplasia, vaginal agenesis, or Mayer–Rokitansky–Küster–Hauser syndrome (MRKH syndrome), is a congenital malformation characterized by a failure of the Müllerian ducts to develop, resulting in a missing uterus and variable degrees of vaginal hypoplasia of its upper portion.