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January 2007 Dennis Paustenbach, who was the founder of ChemRisk, co-authored an article entitled "A methodology for estimating human exposure to perfluorooctanoic acid (PFOA): a retrospective exposure assessment of a community (1951-2003)" in the Journal of Toxicology and Environmental Health, in which the authors said that " The predicted ...
Exposure to PFAS is a risk factor for various hypertensive disorders in pregnancy, including preeclampsia and high blood pressure. It is not clear whether PFAS exposure is associated with wider cardiovascular disorders during pregnancy. [77] Human breast milk can harbor PFASs, which can be transferred from mother to infant via breastfeeding ...
Perfluorooctanesulfonic acid (PFOS) (conjugate base perfluorooctanesulfonate) is a chemical compound having an eight-carbon fluorocarbon chain and a sulfonic acid functional group, and thus it is a perfluorosulfonic acid and a perfluoroalkyl substance (PFAS).
Certain perfluoroalkyl substances (PFAS), which are a type of CEC, have been linked to different adverse health outcomes like increased cholesterol levels, changes in liver enzymes, and reduced vaccine efficacy, which raises concerns about widespread exposure to these chemicals. [45]
Notably, GenX exposure led to altered expression of α-synuclein, a protein closely linked to the development of Parkinson's disease. The findings suggest that developmental exposure to GenX may pose a long-term risk for neurodegenerative disorders, particularly Parkinson's disease, due to its impact on key neuronal processes.
[11] [12] Nevertheless, evidence of exposure can be detected amongst people with historic exposure. Serum concentrations of PFHxS were elevated amongst a cohort of Australian firefighters with occupational exposure to PFHxS (mean = 33 μg/L) compared to the general Australian population (mean = 3.2 μg/L), and were significantly correlated with ...
In 1995, the Governing Council of the United Nations Environment Programme (UNEP) called for global action to be taken on POPs, which it defined as "chemical substances that persist in the environment, bio-accumulate through the food web, and pose a risk of causing adverse effects to human health and the environment".
Via contaminated water or soil, plants can take up PFDA. This may lead to exposure and accumulation of PFDA in humans and other organisms. [5] In addition, exposure is possible via inhalation of indoor and outdoor air and ingestion of drinking water and food. [3] Direct dermal contact with PFDA-containing products is the main route of exposure. [5]