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Dostarlimab was approved for the treatment of endometrial cancer in both the United States and the European Union in April 2021. [ 5 ] [ 6 ] [ 11 ] [ 8 ] [ 12 ] Based on the Garnet trial, dostarlimab gained accelerated approval from the US Food and Drug Administration (FDA) in April 2021, [ 6 ] and full approval in February 2023.
Most alternative cancer treatments have not been tested in proper clinical trials. Among studies that have been published, the quality is often poor. A 2006 review of 196 clinical trials that studied unconventional cancer treatments found a lack of early-phase testing, little rationale for dosing regimens, and poor statistical analyses. [11]
Treatment of uterine cancer may differ depending on the type of cancer and staging of the tumor. [15] In early stages, minimal invasive surgery is preferred. [16] For endometrial cancer, five main types of treatments are used, including surgery, radiation therapy, chemotherapy, hormone therapy, and targeted therapy
Anthracyclines are a class of drugs used in cancer chemotherapy that are extracted from Streptomyces peucetius bacterium. [2] [3] [4] These compounds are used to treat many cancers, including leukemias, lymphomas, breast, stomach, uterine, ovarian, bladder cancer, and lung cancers.
Obesity is associated with an increased risk of developing gynecologic cancers such as endometrial and ovarian cancer. [14] For endometrial cancer, every 5-unit increase on the BMI scale was associated with a 50-60% increase in risk. [15] Type 1 endometrial cancer is the most common endometrial cancer. [16]
Postmenopausal Black women who reported using hair relaxers more than twice a year or for more than five years had a greater than 50% increased risk of uterine cancer.
The endometrial hyperplasia that leads to endometrial cancer with estrogen therapy can be prevented by concomitant administration of progestogen. [60] The extensive use of high-dose estrogens for birth control in the 1970s is thought to have resulted in a significant increase in the incidence of type 1 endometrial cancer. [61]
An organizer estimates 200 community members shuttled about 26,000 people from Amish weddings to the polls to vote for the Republican nominee.
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