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Central nervous system (CNS) depression is a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness, possibly leading to coma or death. It is the result of inhibited or suppressed brain activity .
These symptoms can significantly impair daily functioning and pose challenges in their personal and professional lives. [1] The exact cause of catatonic depression is not fully understood. [1] However, it is believed to arise from a complex interplay of genetic, biochemical, and environmental factors.
The symptoms vary widely, as do the treatments. Central nervous system tumors are the most common forms of pediatric cancer. Brain tumors are the most frequent and have the highest mortality. [4] Some disorders, such as substance addiction, autism, and ADHD may be regarded as CNS disorders, though the classifications are not without dispute.
Many of the symptoms of depression are thought to stem from the release of inflammatory cytokines by macrophages in the peripheral and central nervous systems. [71] Cytokines have the potential to impact neural connectivity and neurotransmitter concentrations, subsequently producing physiological alterations in the nervous system and ...
The biology of depression is the attempt to identify a biochemical origin of depression, as opposed to theories that emphasize psychological or situational causes. Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD) . [ 1 ]
There are many psychiatric and medical conditions that may mimic some or all of the symptoms of depression or may occur comorbid to it. [11] [12] [13] A disorder either psychiatric or medical that shares symptoms and characteristics of another disorder, and may be the true cause of the presenting symptoms is known as a differential diagnosis. [14]
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