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In sleep medicine, we use very small doses of melatonin multiple hours before bed to help gradually shift the body’s clock (circadian rhythm) in people with delayed sleep phase disorder, jet lag ...
It is sometimes called the ultradian sleep cycle, sleep–dream cycle, or REM-NREM cycle, to distinguish it from the circadian alternation between sleep and wakefulness. In humans, this cycle takes 70 to 110 minutes (90 ± 20 minutes). [1] Within the sleep of adults and infants there are cyclic fluctuations between quiet and active sleep.
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Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.
This time allows for the body to recharge and return to a phase of optimal functioning. It is recommended that adults get 7 to 9 hours of sleep each night. Sleep is regulated by an internal process known as the circadian rhythm. This 24-hour cycle regulates periods of alertness and tiredness that an individual experiences. [3]
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Physiology professor Nathaniel Kleitman's 1939 book Sleep and Wakefulness, revised 1963, [7] summarized the existing knowledge of sleep, and it was he who proposed the existence of a basic rest-activity cycle. Kleitman, with his students including William C. Dement and Eugene Aserinsky, continued his research throughout the 1900s. O.
In the same review, it was found that in animal studies, oestradiol, the primary form of estrogen, significantly influences sleep and wake cycles while testosterone, the primary male reproductive ...
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