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Idiopathic granulomatous hepatitis is a rare medical condition characterized by granulomas in the liver, recurrent fever, myalgia, and fatigue. The condition is not a true hepatitis , and some experts believe it is a variant of sarcoidosis .
The disease is still sometimes confused with lethal midline granuloma and lymphomatoid granulomatosis, both malignant lymphomas. [ 34 ] The full clinical picture was first presented by Friedrich Wegener (1907–1990), a German pathologist , in two reports in 1936 and 1939, leading to the eponymous name Wegener's granulomatosis or Wegener ...
The hepatic form of the disease is the most important, granulomas here giving rise to fibrosis of the liver and hepatosplenomegaly in severe cases. Symptoms and signs depend on the number and location of eggs trapped in the tissues. Initially, the inflammatory reaction is readily reversible.
Chronic granulomatous disease (CGD), also known as Bridges–Good syndrome, chronic granulomatous disorder, and Quie syndrome, [1] is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming the reactive oxygen compounds (most importantly the superoxide radical due to defective phagocyte NADPH oxidase) used to kill certain ingested pathogens. [2]
Bacterial infection of the liver commonly results in pyogenic liver abscesses, acute hepatitis, or granulomatous (or chronic) liver disease. [34] Pyogenic abscesses commonly involve enteric bacteria such as Escherichia coli and Klebsiella pneumoniae and are composed of multiple bacteria up to 50% of the time. [ 34 ]
Fatty liver disease is known as a “silent disease” as it has few symptoms. In fact, you might have fatty liver disease and not even know it. You may not experience any symptoms at all until it ...
The disease usually begins in the lungs, skin, or lymph nodes. [2] Less commonly affected are the eyes, liver, heart, and brain, though any organ can be affected. [2] The signs and symptoms depend on the organ involved. [2] Often, no symptoms or only mild symptoms are seen. [2]
Cerebral granulomatous disease may be caused by S. japonicum eggs in the brain during both the acute and chronic phase of the disease. [26] Communities in China affected by S. japonicum have rates of seizures eight times higher than baseline. [23] Cerebral granulomatous infection may also be caused by S. mansoni.
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