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Eosinophilic gastroenteritis (EG or EGE), also known as eosinophilic enteritis, [1] is a rare and heterogeneous condition characterized by patchy or diffuse eosinophilic infiltration of gastrointestinal (GI) tissue, first described by Kaijser in 1937.
Eosinophilic enteropathy A condition in which eosinophils (a type of white blood cell ) accumulate in the gastrointestinal tract and in the blood. Eosinophil build up in the gastrointestinal tract can result in polyp formation, tissue break down, inflammation , and ulcers .
For treating eosinophilic gastroenteritis, the main treatment is usually a corticosteroid medication, as these have been shown to have good efficacy in managing eosinophilic gastroenteritis. Other treatments include modifying diets to avoid food allergies, azathioprine and antibodies, including mepolizumab , omalizumab , infliximab , and ...
Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds 5 × 10 8 /L (500/μL). [1] Hypereosinophilia is an elevation in an individual's circulating blood eosinophil count above 1.5 × 10 9 /L (i.e. 1,500/μL).
For instance, patients with eosinophilic asthma have high levels of eosinophils that lead to inflammation and tissue damage, making it more difficult for patients to breathe. [ 6 ] [ 7 ] Eosinophils persist in the circulation for 8–12 hours, and can survive in tissue for an additional 8–12 days in the absence of stimulation. [ 8 ]
Eosinophilic (Greek suffix -phil-, meaning loves eosin) is the staining of tissues, cells, or organelles after they have been washed with eosin, a dye. Eosin is an acidic dye for staining cell cytoplasm , collagen , and muscle fibers .
Gastroenteritis is the main reason for 3.7 million visits to physicians a year in the United States [1] and 3 million visits in France. [81] In the United States gastroenteritis as a whole is believed to result in costs of US$23 billion per year, [82] with rotavirus alone resulting in estimated costs of US$1 billion a year. [1]
Autoimmune enteropathy is a rare autoimmune disorder characterized by weight loss from malabsorption, severe and protracted diarrhea, and autoimmune damage to the intestinal mucosa. [1]