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Chronic diarrhea may be caused by excess bile salts entering the colon rather than being absorbed at the end of the small intestine (the ileum). This condition of bile acid malabsorption occurs after surgery to the ileum , in Crohn's disease , with a number of other gastrointestinal causes, or is commonly a primary, idiopathic condition.
Chronic diarrhea in postcholecystectomy syndrome is a type of bile acid diarrhea (type 3). [3] This can be treated with a bile acid sequestrant like cholestyramine, [3] colestipol [2] or colesevelam, [7] which may be better tolerated. [8]
Most people with previous ileal resection and chronic diarrhea will have abnormal SeHCAT tests and can benefit from bile acid sequestrants. [4] People with primary bile acid diarrhea are frequently misdiagnosed as having irritable bowel syndrome. [17] When SeHCAT testing is performed, the diagnosis of primary bile acid diarrhea is commonly made.
SeHCAT is a taurine-conjugated bile acid analog which was synthesized for use as a radiopharmaceutical to investigate in vivo the enterohepatic circulation of bile salts. [2] By incorporating the gamma-emitter 75 Se into the SeHCAT molecule, the retention in the body or the loss of this compound into the feces could be studied easily using a standard gamma camera, available in most clinical ...
Depending on the nature of the disease process causing malabsorption and its extent, gastrointestinal symptoms may range from severe to subtle or may even be totally absent. Diarrhea , weight loss , flatulence , abdominal bloating , abdominal cramps , and pain may be present.
Colesevelam is part of a class of drugs known as bile acid sequestrants. Colesevelam hydrochloride, the active pharmaceutical ingredient in Welchol, is a non-absorbed, lipid-lowering polymer that binds bile acids in the intestine, impeding their reabsorption. As the bile acid pool becomes depleted, the hepatic enzyme, cholesterol 7-α ...
Clostridium species can cause diarrhea in dogs. Associated species include C. perfringens and Clostridioides difficile. [13] Kennel cough is an infectious respiratory disease that can be caused by one of several viruses or by Bordetella bronchiseptica. It most commonly occurs in dogs in close confinement such as in kennels.
Pages in category "Bile acid sequestrants" The following 6 pages are in this category, out of 6 total. This list may not reflect recent changes. B. Bile acid ...