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Creutzfeldt–Jakob disease (CJD), also known as subacute spongiform encephalopathy or neurocognitive disorder due to prion disease, is a fatal neurodegenerative disease. [ 4 ] [ 1 ] Early symptoms include memory problems, behavioral changes, poor coordination, and visual disturbances. [ 4 ]
Hans Gerhard Creutzfeldt (June 2, 1885 – December 30, 1964) was a German neurologist and neuropathologist. [1] Although he is typically credited as the physician to first describe the Creutzfeldt–Jakob disease, this has been disputed. [1] [2] [3] He was born in Harburg an der Elbe and died in Munich.
The United Kingdom was afflicted with an outbreak of bovine spongiform encephalopathy (BSE, also known as "mad cow disease"), and its human equivalent variant Creutzfeldt–Jakob disease (vCJD), in the 1980s and 1990s. Over four million head of cattle were slaughtered in an effort to contain the outbreak, and 178 people died after contracting ...
Stanley Prusiner was awarded the Nobel Prize in Physiology or Medicine in 1997 for his work in proposing an explanation for the cause of bovine spongiform encephalopathy ("mad cow disease") and its human equivalent, Creutzfeldt–Jakob disease. [3]
The lab of EE Manuelidis and L Manuelidis was the first to serially transmit human Creutzfeldt–Jakob disease (CJD) to guinea pigs and small rodents. [22] [23] [24] This made it possible to demonstrate fundamental mechanisms of infection, including TSE agent uptake and spread via myeloid cells of the blood, [25] [26] a common route for most ...
Electroencephalogram (EEG) is used to distinguish kuru from Creutzfeldt–Jakob disease, a similar encephalopathy (any disease that affects the structure of the brain). [28] EEGs search for electrical activity in the person's brain and measure the frequency of each wave to determine if there is an issue with the brain's activity. [29]
Creutzfeldt–Jakob disease: Neurology Autosomal dominant PRNP: 1/24,000 Libya Cerebrotendinous xanthomatosis: Medical genetics, endocrinology Autosomal recessive CYP27A1: 1/70 Morocco Cystinuria: Endocrinology Autosomal recessive SLC7A9: 1/25 Libya Familial Mediterranean fever: Rheumatology, immunology Autosomal recessive MEFV: 1/5–7
View history; Tools. Tools. move to sidebar hide. Actions ... Creutzfeldt–Jakob disease, rare disease of the brain caused by prions;