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Treatment is dependent on the severity of the discontinuation reaction and whether or not further antidepressant treatment is warranted. In cases where further antidepressant treatment is prescribed, then the only option suggested may be restarting the antidepressant. If antidepressants are no longer required, treatment depends on symptom severity.
NDRIs are used clinically in the treatment of conditions including attention deficit hyperactivity disorder (ADHD), narcolepsy, and depression. Examples of well-known NDRIs include methylphenidate and bupropion. A closely related type of drug is a norepinephrine–dopamine releasing agent (NDRA).
These drugs inhibit the uptake of the neurotransmitter 5-HT by blocking the SERT, thus increasing its synaptic concentration, and have shown to be efficacious in the treatment of depression, however sexual dysfunction and weight gain are two very common side-effects that result in discontinuation of treatment.
As Americans are increasingly reaching for pharmaceutical solutions for depression—about one in eight U.S. adults takes antidepressants—scientists have been innovating novel treatments for it.
Amitriptyline (Elavil) is FDA-approved for the treatment of depression in adults. Off-label, it may be prescribed to treat everything from sleep disorders to chronic pain to PTSD.
This new insight on ADHD is further reflected in the DSM-5, which lists ADHD as a “lifespan neurodevelopmental condition,” and has distinct requirements for children and adults. Per DSM-5 criteria, children must display “six or more symptoms in either the inattentive or hyperactive-impulsive domain, or both,” for the diagnosis of ADHD. [3]
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