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The distinguishing characteristics of POIS are: the rapid onset of symptoms after orgasm; the presence of an overwhelming systemic reaction. [1]POIS symptoms, which are called a "POIS attack", [1] can include some combination of the following: cognitive dysfunction, aphasia, severe muscle pain throughout the body, severe fatigue, weakness, and flu-like or allergy-like symptoms, [4] such as ...
Glutamate is the most abundant excitatory neurotransmitter in the vertebrate nervous system. [60] Increased glutamate excitatory activity during withdrawal may lead to sensitization or kindling of the CNS, possibly leading to worsening cognition and symptomatology and making each subsequent withdrawal period worse.
Another damaging result of excess calcium in the cytosol is the opening of the mitochondrial permeability transition pore, a pore in the membranes of mitochondria that opens when the organelles absorb too much calcium. Opening of the pore may cause mitochondria to swell and release reactive oxygen species and other proteins that can lead to ...
Glutamate is a very major constituent of a wide variety of proteins; consequently it is one of the most abundant amino acids in the human body. [1] Glutamate is formally classified as a non-essential amino acid, because it can be synthesized (in sufficient quantities for health) from α-ketoglutaric acid, which is produced as part of the citric acid cycle by a series of reactions whose ...
Augmented calcium levels in the blood (by as much as 25% – known as hypercalcaemia). This can cause stomach upset, excessive urination, and impaired kidney function. [13] Diabetes may be activated or intensified, and its control worsened. The diabetes is ameliorated or may disappear when the thyrotoxicosis is treated. [4]
Less common side effects of bicalutamide monotherapy in men include sexual dysfunction, depression, fatigue, weakness, and anemia. Bicalutamide is well tolerated and has few side effects in women. General side effects of bicalutamide that may occur in either sex include diarrhea, constipation, abdominal pain, nausea, dry skin, itching, and rash.
Sensory overload, [12] emotional distress, injury, sleep deprivation, infections, and spending too long standing or sitting up are other potential triggers. [6] The resulting symptoms are disproportionate to the triggering activity and are often debilitating, potentially rendering someone housebound or bedbound until they recover.
Severe fatigue may come on suddenly and make it difficult to be active at all. [33] The impact of fatigue can be severe and pose more of a problem than the pain. [35] Fatigue is a complicated, multifactorial, and vexing symptom that is highly prevalent (76%) and stubbornly persistent, as evidenced by longitudinal studies over 5 years. [36]