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The area of the brain most damaged in early Huntington's disease is the dorsal striatum made up of the caudate nucleus and the putamen. Initially, damage to the brain is regionally specific with the dorsal striatum in the subcortical basal ganglia being primarily affected, followed later by cortical involvement in all areas.
Scientists at the Broad Institute of MIT and Harvard, McLean Hospital in Massachusetts and Harvard Medical School studied brain tissue donated by 53 people with Huntington’s and 50 without it ...
Huntingtin (Htt) is the protein coded for in humans by the HTT gene, also known as the IT15 ("interesting transcript 15") gene. [5] Mutated HTT is the cause of Huntington's disease (HD), and has been investigated for this role and also for its involvement in long-term memory storage.
Huntington's disease is a hereditary disease that causes defects in behavior, cognition, and uncontrolled rapid, jerky movements. [1] Huntington's disease stems from a defect that consists of an expanded CAG repeat in the huntingtin gene (HTT) located on the short arm p of chromosome 4 . [ 7 ]
The Visible Human Project is an effort to create a detailed data set of cross-sectional photographs of the human body, in order to facilitate anatomy visualization applications. It is used as a tool for the progression of medical findings, in which these findings link anatomy to its audiences. [ 1 ]
Huntington's disease is a degenerative neurological disorder that is inherited. Degeneration of neuronal cells occurs throughout the brain, especially in the striatum. There is a progressive decline that results in abnormal movements. [31] Statistics show that Huntington's disease may affect 10 per 100,000 people of Western European descent.
Most disorders that are associated with damage to these areas of the brain involve some type of motor dysfunction, as well as trouble with mental switching between tasks in working memory. Such symptoms are often present in those who suffer from dystonia, athymhormic syndrome, Fahr's syndrome, Huntington's disease or Parkinson's disease ...
The following diseases and disorders are linked with the putamen: Cognitive decline in Alzheimer's disease [18] Huntington's disease; Wilson's disease; Dementia with Lewy bodies; Corticobasal degeneration; Tourette syndrome; Schizophrenia; Depression; Attention deficit hyperactivity disorder [19] Chorea; Obsessive-Compulsive Disorder [20] [21 ...
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