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Cilostazol, sold under the brand name Pletal among others, is a medication used to help the symptoms of intermittent claudication in peripheral vascular disease. [2] If no improvement is seen after 3 months, stopping the medication is reasonable. [ 3 ]
PDE3 inhibitors are a type of phosphodiesterase inhibitors.Inhibition of the PDE isoenzyme 3 leads to an increase of intracellular concentrations of the second messenger cyclic adenosine monophosphate (cAMP). cAMP mediates the phosphorylation of protein kinases, which in turn activates cardiac calcium channels.
Cilostazol is approved for treatment of intermittent claudication and is thought to involve inhibition of platelet aggregation and also inhibition of smooth muscle proliferation and vasodilation. The most studied roles of PDE3B have been in the areas of insulin , IGF1 , and leptin signaling. [ 1 ]
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Over-the-counter (OTC) drugs are medicines sold directly to a consumer without a requirement for a prescription from a healthcare professional, [1] as opposed to prescription drugs, which may be supplied only to consumers possessing a valid prescription.
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Treatment of worm infections is mostly limited to cats kept in human care. Most infections are rather harmless for cats, since a pathogen-host balance is established when the immune system is intact. However, because some of them can cause health disorders and some also pose a potential danger to humans, regular deworming for cats in the human ...
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