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The biggest risk of anticoagulation therapy is the increased risk of bleeding. [15] In otherwise healthy people, the increased risk of bleeding is minimal, but those who have had recent surgery, cerebral aneurysms , and other conditions may have too great a risk of bleeding.
Internal bleeding could be a result of complications following surgery or other medical procedures. Some medications may also increase a person's risk for bleeding, such as anticoagulant drugs or antiplatelet drugs in the treatment of coronary artery disease. [10]
However, further studies have shown that taking low-dose aspirin daily can increase the risk of bleeding in some older adults — including bleeding in the stomach, intestines, and brain, which ...
A number of medications are found to cause upper GI bleeds. [16] NSAIDs or COX-2 inhibitors increase the risk about fourfold. [16] SSRIs, corticosteroids, and anticoagulants may also increase the risk. [16] The risk with dabigatran is 30% greater than that with warfarin. [17]
NSAIDs cause decreased ability to form blood clots, which can increase the risk of bleeding when combined with other drugs that also decrease blood clotting, such as warfarin. [113] NSAIDs may aggravate hypertension (high blood pressure) and thereby antagonize the effect of antihypertensives, [113] such as ACE inhibitors. [114]
All types of bleeding occur more commonly, but the most severe ones are those involving the brain (intracerebral hemorrhage/hemorrhagic stroke) and the spinal cord. [30] Risk of bleeding is increased if the INR is out of range (due to accidental or deliberate overdose or due to interactions). [45] This risk increases greatly once the INR ...
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In addition to NSAID-related bleeding, another common cause of bleeding is that related to the medication, warfarin ("Coumadin" and others). This medication needs to be closely monitored as the bleeding risk can be markedly increased by interactions with other medications. Warfarin acts by inhibiting the production of Vitamin K in the gut ...