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Serious side effects may include rhabdomyolysis, liver problems, and diabetes. [5] Use during pregnancy may harm the fetus. [5] Like all statins, pravastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver that plays a role in producing cholesterol. [5] Pravastatin was patented in 1980 and approved for medical use in 1989. [6]
The most important adverse side effects are muscle problems, an increased risk of diabetes mellitus, and increased liver enzymes in the blood due to liver damage. [5] [65] Over 5 years of treatment statins result in 75 cases of diabetes, 7.5 cases of bleeding stroke, and 5 cases of muscle damage per 10,000 people treated. [34]
The most common side effects are abdominal distension (bloating), abdominal pain (stomach ache), constipation, diarrhea, dry mouth, dyspepsia (heartburn), eructation (belching), flatulence (gas), nausea (feeling sick), abdominal discomfort, vomiting and raised blood levels of liver enzymes.
Overall, our findings suggest that more people over 70 years of age should be considered for statin treatment.” — Borislava Mihaylova, DPhil “Cardiovascular disease remains a leading cause ...
“A doctor might recommend Tylenol over ibuprofen for patients who need pain relief but cannot tolerate NSAIDs due to stomach issues, risk of bleeding, or cardiovascular concerns,” says Walia ...
Atherosclerosis generally starts when a person is young and worsens with age. Women are 78% at higher risk level than men [2] Almost all people are affected to some degree by the age of 65. [7] It is the number one cause of death and disability in developed countries.
Ariana Grande stuns Drew Barrymore with heartfelt message during 'Wicked' interview "I don't know too much about what your relationship has been to this industry the whole time, but I do know what ...
The long-term effects of HRT on most organ systems vary by age and time since the last physiological exposure to hormones, and there can be large differences in individual regimens, factors which have made analyzing effects difficult. [6] The Women's Health Initiative (WHI) is an ongoing study of over 27,000 women that began in 1991, with the ...