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Hemolytic–uremic syndrome (HUS) is a group of blood disorders characterized by low red blood cells, acute kidney injury (previously called acute renal failure), and low platelets. [1] [3] Initial symptoms typically include bloody diarrhea, fever, vomiting, and weakness. [1] [2] Kidney problems and low platelets then occur as the diarrhea ...
In children, a complication can be hemolytic uremic syndrome which then uses cytotoxins to attack the cells in the gut, so that bacteria can leak out into the blood and cause endothelial injury in locations such as the kidney by binding to globotriaosylceramide (Gb3). [citation needed] EHECs that induce bloody diarrhea lead to HUS in 10% of cases.
Acute kidney injuries can be present on top of chronic kidney disease, a condition called acute-on-chronic kidney failure (AoCRF). The acute part of AoCRF may be reversible, and the goal of treatment, as with AKI, is to return the person to baseline kidney function, typically measured by serum creatinine .
Hemolytic-uremic syndrome: D59.3: 13052: Hemolytic-uremic syndrome (HUS) (also known as haemolytic-uraemic syndrome) is a disease characterized by hemolytic anemia, acute renal failure and a low platelet count (thrombocytopenia). It predominantly but not exclusively affects children.
Escherichia coli O121 is a pathogenic serotype of Escherichia coli, [1] associated with Shiga toxin, intestinal bleeding, and hemolytic-uremic syndrome (HUS). [2] HUS, if left untreated, can lead to kidney failure. [citation needed]
A glomerular filtration rate (GFR) ≥ 60 mL/min/1.73 m 2 is considered normal without chronic kidney disease if there is no kidney damage present. Kidney damage is defined signs of damage seen in blood, urine, or imaging studies which includes lab albumin/creatinine ratio (ACR) ≥ 30. [ 59 ]
This is the filtering structure that is a key to the function of the kidney. Destroying these structures leads to kidney failure and the development of the often deadly and frequently debilitating hemolytic uremic syndrome. Food poisoning with Shiga toxin often also has effects on the lungs and the nervous system.
Nephritic syndrome is a syndrome comprising signs of nephritis, which is kidney disease involving inflammation. It often occurs in the glomerulus , where it is called glomerulonephritis . Glomerulonephritis is characterized by inflammation and thinning of the glomerular basement membrane and the occurrence of small pores in the podocytes of the ...