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ARIA-E refers to cerebral edema, involving the breakdown of the tight endothelial junctions of the blood-brain barrier and subsequent accumulation of fluid. [3] In a double-blind trial of the humanised monoclonal antibody solanezumab (n = 2042), sixteen patients (11 taking the drug, 5 taking a placebo), or 0.78% developed ARIA-E.
Neuroinflammation is widely regarded as chronic, as opposed to acute, inflammation of the central nervous system. [5] Acute inflammation usually follows injury to the central nervous system immediately, and is characterized by inflammatory molecules, endothelial cell activation, platelet deposition, and tissue edema. [6]
Most IIAs are caused by bacterial infection, most commonly Staphylococcus aureus and Streptococcus species. In most cases the infection originates from left-sided bacterial endocarditis. [1] Other common sources include cavernous sinus thrombosis, bacterial meningitis, poor dental hygiene and intravenous drug use. The use of the term infectious ...
Satellite photograph of a mesa in the Cydonia region of Mars, often called the "Face on Mars" and cited as evidence of extraterrestrial habitation. Pareidolia (/ ˌ p ær ɪ ˈ d oʊ l i ə, ˌ p ɛər-/; [1] also US: / ˌ p ɛər aɪ-/) [2] is the tendency for perception to impose a meaningful interpretation on a nebulous stimulus, usually visual, so that one detects an object, pattern, or ...
Brain oedema formation is due to the breakdown of red blood cells, where haemoglobin and other contents of red blood cells are released. The release of these red blood cells contents causes toxic effect on the brain and causes brain oedema. Besides, the breaking down of blood-brain barrier also contributes to the odema formation. [13]
The development of the nervous system in humans, or neural development, or neurodevelopment involves the studies of embryology, developmental biology, and neuroscience.These describe the cellular and molecular mechanisms by which the complex nervous system forms in humans, develops during prenatal development, and continues to develop postnatally.
Electroencephalogram (EEG) is used to distinguish kuru from Creutzfeldt–Jakob disease, a similar encephalopathy (any disease that affects the structure of the brain). [28] EEGs search for electrical activity in the person's brain and measure the frequency of each wave to determine if there is an issue with the brain's activity. [29]
PML is diagnosed in a patient with a progressive course of the disease, finding JC virus DNA in spinal fluid together with consistent white-matter lesions on brain magnetic resonance imaging (MRI); alternatively, a brain biopsy is diagnostic [1] when the typical histopathology of demyelination, bizarre astrocytes, and enlarged oligodendroglial ...