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Endogenous depression is an atypical subclass of major depressive disorder (clinical depression). It could be caused by genetic and biological factors. [ 1 ] Endogenous depression occurs due to the presence of an internal (cognitive, biological) stressor instead of an external (social, environmental) stressor. [ 2 ]
This article needs to be updated. The reason given is: Many outdated sources and information (older than five years). Please help update this article to reflect recent events or newly available information. (July 2024) Medical condition Major depressive disorder Other names Clinical depression, major depression, unipolar depression, unipolar disorder, recurrent depression Sorrowing Old Man (At ...
The biology of depression is the attempt to identify a biochemical origin of depression, as opposed to theories that emphasize psychological or situational causes. Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD) . [ 1 ]
The cause of depression is believed to be due to a combined effect of genetic and environmental factors. [11] Other medical conditions, for example hypothyroidism, may cause people to experience similar symptoms as a major depressive episode. [20]
Depression, one of the most commonly diagnosed psychiatric disorders, [2] [3] is being diagnosed in increasing numbers in various segments of the population worldwide. [4] [5] Depression in the United States alone affects 17.6 million Americans each year or 1 in 6 people. Depressed patients are at increased risk of type 2 diabetes ...
Dreyfus had challenged (in 1907) Kraepelin's concept of an acquired origin, maintaining it to be endogenous in origin (although statistical review of Dreyfus's analysis of his case series has questioned his conclusion that the natural history of involutional melancholia was similar to that of depression in younger people). [3]
“Depression may result from health concerns like diabetes, heart disease, and cancer,” says Dr. Riba. “And medications can impact mood and bring on depressive symptoms , too.”
The HPA axis appears to be dysregulated in psychotic depression, with dexamethasone suppression tests demonstrating higher levels of cortisol following dexamethasone administration (i.e. lower cortisol suppression). [2] Those with psychotic depression also have higher ventricular-brain ratios than those with non-psychotic depression. [2]
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