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The microbiome is defined as a characteristic microbial community occupying a reasonable well-defined habitat which has distinct physio-chemical properties. The microbiome not only refers to the microorganisms involved but also encompass their theatre of activity, which results in the formation of specific ecological niches.
The microbiome and host emerged during evolution as a synergistic unit from epigenetics and genetic characteristics, sometimes collectively referred to as a holobiont. [ 7 ] [ 8 ] The presence of microbiota in human and other metazoan guts has been critical for understanding the co-evolution between metazoans and bacteria.
QIIME (English: / tʃ aɪ m / ch-eye-m) [1] is a bioinformatics data science platform, originally developed for analysis of high-throughput microbiome marker gene (e.g., 16S or 18S rRNA genes) amplicon sequencing data. There have been two major versions of the QIIME platform, QIIME 1 [2] and QIIME 2. [3]
[33] [34] The ways the microbiome influences human and animal health, as well as methods to influence the microbiome are active areas of research. [35] Research has suggested that microorganisms could be useful in the treatment of cancer. Various strains of non-pathogenic clostridia can infiltrate and replicate within solid tumors. Clostridial ...
Human microbiota plays a central role in health and diseases and disruption of the microbiome leads to dysbiosis (the relationship between microbiota and host is linked to illnesses etc.). [10] Unlike other human microbiomes, the oral microbiome is in dysbiosis causing disease in a majority of people in their lifetime. [3]
The human microbiome is the aggregate of all microbiota that reside on or within human tissues and biofluids along with the corresponding anatomical sites in which they reside, [1] [2] including the gastrointestinal tract, skin, mammary glands, seminal fluid, uterus, ovarian follicles, lung, saliva, oral mucosa, conjunctiva, and the biliary tract.
Metatranscriptomics is the set of techniques used to study gene expression of microbes within natural environments, i.e., the metatranscriptome. [1]While metagenomics focuses on studying the genomic content and on identifying which microbes are present within a community, metatranscriptomics can be used to study the diversity of the active genes within such community, to quantify their ...
In 2016, the journal Microbiome published a collection of various works studying the microbial ecology of the built environment. [ 69 ] A 2006 study of pathogenic bacteria in hospitals found that their ability to survive varied by the type, with some surviving for only a few days while others survived for months.