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Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune disease of the liver. [1] [2] [3] It results from a slow, progressive destruction of the small bile ducts of the liver, causing bile and other toxins to build up in the liver, a condition called cholestasis.
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1–2 people per 100,000 per year (Western world) [6] Cholangiocarcinoma , also known as bile duct cancer , is a type of cancer that forms in the bile ducts . [ 2 ] Symptoms of cholangiocarcinoma may include abdominal pain , yellowish skin , weight loss , generalized itching , and fever. [ 1 ]
Portal hypertension is defined as increased portal venous pressure, with a hepatic venous pressure gradient greater than 5 mmHg. [3] [4] Normal portal pressure is 1–4 mmHg; clinically insignificant portal hypertension is present at portal pressures 5–9 mmHg; clinically significant portal hypertension is present at portal pressures greater than 10 mmHg. [5]
In one study, 70% of women who had a heart attack reported this. “It is a significant fatigue that really feels different than just tiredness at the end of a busy day,” says Rosen.
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Early detection of Alzheimer’s disease and related dementias is especially crucial for the 58 million Americans over the age of 65, as existing disease-modifying treatments are effective only in ...
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