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Amiodarone has particularly important interactions with the following drugs: class I antiarrhythmics (amiodarone should not be combined with other class I antiarrhythmic drugs, such as disopyramide, flecainide, procainamide, quinidine, etc., due to an increased risk of QTc prolongation and potential arrhythmias); [13]
Persistent AIT that does not respond to treatment regardless of the subtype will likely have to consider alternatives such as plasmapheresis or surgery. [7] [8] Monitoring is highly recommended for patients taking amiodarone, and thyroid function should be regularly evaluated during treatment and for at least one year following drug cessation. [2]
Amiodarone is also safe to use in individuals with cardiomyopathy and atrial fibrillation, to maintain normal sinus rhythm. Amiodarone prolongation of the action potential is uniform over a wide range of heart rates, so this drug does not have reverse use-dependent action. Amiodarone was the first agent described in this class. [4]
Lung symptoms in a patient who is taking a medicinal drug that can cause pulmonary toxicity should not automatically lead to a diagnosis of "pulmonary toxicity due to the medicinal drug", because some patients can have another (i.e., simultaneous) lung disease, e.g. an infection of the lungs not related to the medicinal drugs the patient is ...
An electrocardiogram (ECG) should be included in the assessment when there is concern of an overdose. [2] In overdose activated charcoal is often recommended. [1] People should not be forced to vomit. [2] In those who have a wide QRS complex (> 100 ms) sodium bicarbonate is recommended. [2] If seizures occur benzodiazepines should be given. [2]
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Budiodarone (ATI-2042) is an antiarrhythmic agent and chemical analog of amiodarone that is currently being studied in clinical trials.Amiodarone is considered the most effective antiarrhythmic drug available, [1] [2] [3] but its adverse side effects, including hepatic, pulmonary and thyroid toxicity as well as multiple drug interactions, [4] are discouraging its use.
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