Search results
Results from the WOW.Com Content Network
Medication discontinuation is the ceasing of a medication treatment for a patient by either the clinician or the patient themself. [1] [2] When initiated by the clinician, it is known as deprescribing. [3] Medication discontinuation is an important medical practice that may be motivated by a number of reasons: [4] [3] Reducing polypharmacy
Since amiodarone can be expressed in breast milk, women taking the drug are advised to stop nursing. It is contraindicated in individuals with sinus nodal bradycardia , atrioventricular block, and second or third-degree heart block who do not have an artificial pacemaker .
In medicine, tapering is the practice of gradually reducing the dosage of a medication to reduce or discontinue it. Generally, tapering is done is to avoid or minimize withdrawal symptoms that arise from neurobiological adaptation to the drug. [1] [2]
Compounds that prolong the action potential: matching the modern classification, with the key drug example being amiodarone, and a surgical example being thyroidectomy. This was not a defining characteristic in an earlier review by Charlier et al. (1968), [ 17 ] but was supported by experimental data presented by Vaughan Williams (1970).
It has been found that many drugs either work primarily by modulating gap junction function or produce unintended side effects. [10] Drugs that inhibit gap junction communication include the antiarrhythmic drug amiodarone, the anti-migraine drug tonabersat; or drugs that promote gap junction conduction, such as rotigaptide and danegaptide.
"Novo Nordisk will phase out, then permanently discontinue Levemir in the U.S. on December 31, 2024," the company said in a statement. ... with sales of its obesity drug Wegovy reaching $1.36 ...
Amiodarone is also safe to use in individuals with cardiomyopathy and atrial fibrillation, to maintain normal sinus rhythm. Amiodarone prolongation of the action potential is uniform over a wide range of heart rates, so this drug does not have reverse use-dependent action. Amiodarone was the first agent described in this class. [4]
However, surging demand for Lilly and Danish rival Novo Nordisk's weight-loss drugs, which can cost more than $1,000 for a month's supply, has prompted numerous sellers to offer compounded ...