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The first such known chimera was probably the Bizzarria, which is a fusion of the Florentine citron and the sour orange. Well-known examples of a graft-chimera are Laburnocytisus 'Adamii' , caused by a fusion of a Laburnum and a broom , and "Family" trees, where multiple varieties of apple or pear are grafted onto the same tree.
In molecular biology, and more importantly high-throughput DNA sequencing, a chimera is a single DNA sequence originating when multiple transcripts or DNA sequences get joined. Chimeras can be considered artifacts and be filtered out from the data during processing [ 1 ] to prevent spurious inferences of biological variation. [ 2 ]
Chimeric genes (literally, made of parts from different sources) form through the combination of portions of two or more coding sequences to produce new genes. These mutations are distinct from fusion genes which merge whole gene sequences into a single reading frame and often retain their original functions.
Chimeric transcripts characterize specific cellular phenotypes and are suspected to function not only in cancer, but also in normal cells. One example of a chimera in normal human cells is generated by trans-splicing of the 5′ exons of the JAZF1 gene on chromosome 7p15 and the 3′ exons of JJAZ1 on chromosome 17q1. This chimeric RNA is ...
A human chimera is a human with a subset of cells with a distinct genotype than other cells, that is, having genetic chimerism.In contrast, an individual where each cell contains genetic material from a human and an animal is called a human–animal hybrid, while an organism that contains a mixture of human and non-human cells would be a human-animal chimera.
Chinese scientists have successfully recombined a mouse’s chromosomes to create the world’s first mammal with fully reprogrammed genes. Using the gene-editing tool CRISPR, researchers from the ...
A chimeric protein including two subunits and a linker protein synthesized via recombinant fusion technology. Fusion proteins or chimeric (kī-ˈmir-ik) proteins (literally, made of parts from different sources) are proteins created through the joining of two or more genes that originally coded for separate proteins.
It Is derived from alternative splicing of the α-chimera gene. [5] α2-Chimerin was shown to be involved and important in cognitive development. The expression of α2-chimerin is present in development so α2-chimerin is essential for cognitive function as it directly leads to functioning cognitive ability in adulthood.