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  2. Rivaroxaban - Wikipedia

    en.wikipedia.org/wiki/Rivaroxaban

    Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication (blood thinner) used to treat and prevent blood clots. [8] Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. [ 8 ]

  3. Direct factor Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

    Antistasin, the first discovered naturally occurring direct Xa inhibitor Rivaroxaban, the first synthetic direct Xa inhibitor marketed as a drug Prior to the introduction of direct factor Xa inhibitors, vitamin K antagonists such as warfarin were the only oral anticoagulants for over 60 years, and together with heparin have been the main blood ...

  4. Discovery and development of direct Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    [20] Rivaroxaban. During the SAR development of rivaroxaban, researchers realized that adding a 5-chlorothiophene-2-carboxamide group to the oxazolidonine core could increase the potency by 200 fold, which had previously been too weak for medical use. In addition to this discovery, a clear preference for the (S)-configuration was confirmed.

  5. Bayer's patent for blood thinner Xarelto invalid, UK ... - AOL

    www.aol.com/news/bayers-patent-blood-thinner...

    The company's blockbuster Xarelto drug generated nearly $4.1 billion in revenue in 2023, according to research firm Statista. ... with a brand name of Xarelto, has now been declared invalid ...

  6. Andexanet alfa - Wikipedia

    en.wikipedia.org/wiki/Andexanet_alfa

    Andexanet alfa, sold under the brand name Andexxa among others, is an antidote for the medications rivaroxaban and apixaban, when reversal of anticoagulation is needed due to uncontrolled bleeding. [8] It has not been found to be useful for other factor Xa inhibitors. [9] It is given by injection into a vein. [9]

  7. Zentiva - Wikipedia

    en.wikipedia.org/wiki/Zentiva

    Zentiva is a pharmaceutical company based in Prague, Czech Republic.The company is developing, manufacturing and marketing a wide range of generic and OTC products.. Zentiva employs more than 4 700 [1] people across Europe and has three manufacturing sites, in Prague, Bucharest and Ankleshwar. [2]

  8. Man, 20, Found Dead at Bottom of Elevator Shaft During First ...

    www.aol.com/man-20-found-dead-bottom-160430887.html

    The family of a 20-year-old man is speaking out after he was found dead at the bottom of a hotel elevator shaft in Turkey while reportedly on his first vacation with his girlfriend.

  9. Prisoners of Profit - The Huffington Post

    projects.huffingtonpost.com/prisoners-of-profit?...

    In 2001, an 18-year-old committed to a Texas boot camp operated by one of Slattery’s previous companies, Correctional Services Corp., came down with pneumonia and pleaded to see a doctor as he struggled to breathe.