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The hook effect refers to the prozone phenomenon, also known as antibody excess, or the postzone phenomenon, also known as antigen excess. It is an immunologic phenomenon whereby the effectiveness of antibodies to form immune complexes can be impaired when concentrations of an antibody or an antigen are very high.
A hook effect is commonly observed with high concentrations of PROTACs due to the bifunctional nature of the degrader. [15] Currently, pVHL and CRBN have been used in preclinical trials as E3 ligases. [15] However, there still remains hundreds of E3 ligases to be explored, with some giving the opportunity for cell specificity.
For example, if a test sample returns an OD of 1.0, the point on the standard curve that gave OD = 1.0 must be of the same analyte concentration as the sample. [citation needed] The use and meaning of the names "indirect ELISA" and "direct ELISA" differs in the literature and on web sites depending on the context of the experiment.
For example, imagine a plate wherein compound A is in wells 1–2–3, compound B is in wells 2–3–4, and compound C is in wells 3–4–5. In an assay of this plate against a given target, a hit in wells 2, 3, and 4 would indicate that compound B is the most likely agent, while also providing three measurements of compound B's efficacy ...
For example, someone who is 50 years old but has a biological age of 55 might notice their body isn’t working as well as it should. While this idea might sound a bit abstract, past research has ...
A NASA illustration of a lateral flow assay. A lateral flow test (LFT), [1] is an assay also known as a lateral flow device (LFD), lateral flow immunochromatographic assay, or rapid test.
The ADL conducted a field experiment that sent out 3,000 applications for administrative assistant job postings via Craigslist.org between May and October of this year in 23 cities across the country.
Can we imagine ourselves back on that awful day in the summer of 2010, in the hot firefight that went on for nine hours? Men frenzied with exhaustion and reckless exuberance, eyes and throats burning from dust and smoke, in a battle that erupted after Taliban insurgents castrated a young boy in the village, knowing his family would summon nearby Marines for help and the Marines would come ...