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In osteoarthritis, joint injection of glucocorticoids (such as hydrocortisone) leads to short term pain relief that may last between a few weeks and a few months. [5] Injections of hyaluronic acid have not produced improvement compared to placebo for knee arthritis, [6] [7] but did increase risk of further pain. [6]
Hydrocortisone is the name for the hormone cortisol when supplied as a medication. [14] It is a corticosteroid and works as an anti-inflammatory and by immune suppression . [ 1 ] Uses include conditions such as adrenocortical insufficiency , adrenogenital syndrome , high blood calcium , thyroiditis , rheumatoid arthritis , dermatitis , asthma ...
In pharmacologic (supraphysiologic) doses, glucocorticoids, such as prednisone, dexamethasone, and hydrocortisone are used to suppress various allergic, inflammatory, and autoimmune disorders. They are also administered as posttransplantory immunosuppressants to prevent the acute transplant rejection and graft-versus-host disease .
Hydrocortisone was discovered by Nobel laureates Edward C. Kendall and Philip S. Hench in the 1930s while they were conducting research on rheumatoid arthritis. [14] [15] [16] Its topical use was first recorded in the 1950s. [17] [18] The most common adverse effects after the application of topical hydrocortisone are burning and stinging ...
Therapeutic doses may cause a feeling of artificial well-being ("steroid euphoria"). [22] The neuropsychiatric effects are partly mediated by sensitization of the body to the actions of adrenaline. Therapeutically, the bulk of corticosteroid dose is given in the morning to mimic the body's diurnal rhythm; if given at night, the feeling of being ...
Hydrocortisone sodium succinate, sold under the brand name Solu-Cortef among others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. [ 3 ] Hydrocortisone sodium succinate was approved for medical use in the United States in 1955.
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