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0.75 mg/day: 1.5 mg/day: 3 mg/day Estriol: 1–2 mg/day: 2–4 mg/day: 4–8 mg/day Ethinylestradiol a: 2.5–10 μg/day: 5–20 μg/day – Nasal spray: Estradiol: 150 μg/day: 300 μg/day: 600 μg/day Transdermal patch: Estradiol: 25 μg/day b: 50 μg/day b: 100 μg/day b: Transdermal gel: Estradiol: 0.5 mg/day: 1–1.5 mg/day: 2–3 mg/day ...
Conjugated estrogens (Premarin) – 25 mg/vial; Estradiol cypionate (Depo-Estradiol, Estradiol Cypionate) – 5 mg/mL (1 mg/mL and 3 mg/mL discontinued) Estradiol valerate (Delestrogen, Estradiol Valerate) – 10 mg/mL, 20 mg/mL, 40 mg/mL; Polyestradiol phosphate (Estradurin) was previously available in the U.S. but was discontinued.
1.0: 1.0: 1.0: 1.0: 1.0 ... a 100 μg/day Climara estradiol patch may be expected to produce ... it has also been found that 6 mg/day estradiol gel is effective for ...
New patch used once a week, after 3 weeks patch is not worn to allow for withdrawal bleeding [19] ... Estradiol alone ≤1 mg/day >1 mg/day: 1.27 (1.16–1.39)*
The influence of 2 mg/day oral estradiol on levels of hepatic proteins such as SHBG, CBG, and AGT is much lower than that with 10 μg/day oral ethinylestradiol. [128] [68] Vaginal micronized estradiol at 0.25 mg/day increased SHBG levels by about 10% after 2 weeks of therapy in women.
The influence of 2 mg/day oral estradiol valerate on coagulation factors is less than that of 10 μg/day oral ethinylestradiol. [93] [26] [94] [95] [96] Oral ethinylestradiol at 10 μg/day has been found to have about 1.5- to 2.5-fold the impact of 2 mg/day oral estradiol valerate on HDL cholesterol and triglycerides.
Estradiol cypionate 5 mg + levonorgestrel butanoate 7 mg in an aqueous suspension [16] Estradiol benzoate 5 to 10 mg + norethisterone enanthate 50 to 100 mg [62] Mestranol 1.0–1.2 mg + norethisterone 10–12 mg in a microcrystalline aqueous suspension of defined particle sizes (125–177 μm) [25] [16] [62] [32] Ethinylestradiol ...
Levels of estradiol, testosterone, and gonadotropins with 4.5 μg/kg injectable estradiol benzoate every 12 hours (or ~0.63 mg/day for a 70-kg [154-lb] person) in transgender women. [ 69 ] As with other estrogens and forms of estradiol, [ 70 ] [ 71 ] [ 72 ] estradiol benzoate dose-dependently suppresses gonadotropin and testosterone levels in ...