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The American Cancer Society says that laboratory studies have shown that acrylamide is likely to be a carcinogen, but that as of 2019 evidence from epidemiological studies suggests that dietary acrylamide is unlikely to raise the risk of people developing most common types of cancer. [8]
The chemical acrylamide is considered "probably carcinogenic" by the International Agency for Research on Cancer, and California considers it a substance that's "known to cause cancer." But ...
“Large amounts of acrylamide has been shown to cause cancer in animal models, but there’s no compelling evidence showing that it increases the risk of cancer in humans,” says Catherine ...
Glycidamide is a reactive epoxide metabolite from acrylamide [4] [5] and can react with nucleophiles.This results in covalent binding of the electrophile. [6]Glycidamide gives a positive response in the Ames/Salmonella mutagenicity assay, which indicates that it can cause mutations in the DNA. [4]
Eating burnt food – which contains acrylamide – does not increase the risk of getting cancer. [266] Cancer cannot be treated by reducing sugar and carbohydrate intake to "starve" tumours. [267] It is not just heavy metals which can be toxic; other metals (for example beryllium and lithium) can be toxic too. [268]
Polyacrylamide is of low toxicity but its precursor acrylamide is a neurotoxin and carcinogen. [1] Thus, concerns naturally center on the possibility that polyacrylamide is contaminated with acrylamide. [12] [13] Considerable effort is made to scavenge traces of acrylamide from the polymer intended for use near food. [1]
IARC group 2A agents are substances and exposure circumstances that have been classified as probable carcinogens by the International Agency for Research on Cancer (IARC). [1] This designation is applied when there is limited evidence of carcinogenicity in humans, as well as sufficient evidence of carcinogenicity in experimental animals.
Toast may contain more acrylamide, caused by the browning process, which is suspected to be a carcinogen. [1] However, claims that acrylamide in burnt food causes cancer have not been proven. [2] Butter or margarine, and sweet toppings, such as jam or jelly, are commonly spread on toast.