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  2. Polyclonal B cell response - Wikipedia

    en.wikipedia.org/wiki/Polyclonal_B_cell_response

    Polyclonal response by B cells against linear epitopes [1] Examples of substances recognized as foreign (non-self). Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals.

  3. B cell - Wikipedia

    en.wikipedia.org/wiki/B_cell

    B cell activation occurs in the secondary lymphoid organs (SLOs), such as the spleen and lymph nodes. [1] After B cells mature in the bone marrow, they migrate through the blood to SLOs, which receive a constant supply of antigen through circulating lymph. [14] At the SLO, B cell activation begins when the B cell binds to an antigen via its BCR ...

  4. Persistent polyclonal B-cell lymphocytosis - Wikipedia

    en.wikipedia.org/wiki/Persistent_polyclonal_B...

    Persistent polyclonal B-cell lymphocytosis (PPBL) is an anomaly of the human immune system characterized by mildly elevated levels of white blood cells (called leukocytosis), chronic, stable absolute polyclonal B-cell lymphocytosis, elevated polyclonal IgM and binucleated cells. Although cases of non-smoking women or men have been reported ...

  5. V (D)J recombination - Wikipedia

    en.wikipedia.org/wiki/V(D)J_recombination

    V(D)J recombination (variable–diversity–joining rearrangement) is the mechanism of somatic recombination that occurs only in developing lymphocytes during the early stages of T and B cell maturation. It results in the highly diverse repertoire of antibodies/immunoglobulins and T cell receptors (TCRs) found in B cells and T cells, respectively.

  6. Polyclonal antibodies - Wikipedia

    en.wikipedia.org/wiki/Polyclonal_antibodies

    Polyclonal antibodies (pAbs) are antibodies that are secreted by different B cell lineages within the body (whereas monoclonal antibodies come from a single cell lineage). They are a collection of immunoglobulin molecules that react against a specific antigen , each identifying a different epitope .

  7. Lymphocyte - Wikipedia

    en.wikipedia.org/wiki/Lymphocyte

    A lymphocyte is a type of white blood cell (leukocyte) in the immune system of most vertebrates. [1] Lymphocytes include T cells (for cell-mediated and cytotoxic adaptive immunity), B cells (for humoral, antibody-driven adaptive immunity), [2] [3] and innate lymphoid cells (ILCs; "innate T cell-like" cells involved in mucosal immunity and homeostasis), of which natural killer cells are an ...

  8. BENTA disease - Wikipedia

    en.wikipedia.org/wiki/BENTA_disease

    The majority of patient peripheral blood mononucleated cells are polyclonal naïve mature B cells, with a significant increase in immature, transitional B cell numbers (identified as CD10+). [6] Percentages of circulating class-switched and memory B cells are very low, and in vitro studies show poor B cell differentiation and immunoglobulin ...

  9. Affinity maturation - Wikipedia

    en.wikipedia.org/wiki/Affinity_maturation

    In immunology, affinity maturation is the process by which T FH cell-activated B cells produce antibodies with increased affinity for antigen during the course of an immune response. With repeated exposures to the same antigen, a host will produce antibodies of successively greater affinities .