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  2. Split-intein circular ligation of peptides and proteins

    en.wikipedia.org/wiki/Split-intein_circular...

    Once a cyclic peptide is identified with a biological activity of interest, it may also be possible to identify the target of the peptide (a gene that encodes a protein with which it interacts) by functional complementation, facilitating a better understanding of its mechanism of action.

  3. Arginylglycylaspartic acid - Wikipedia

    en.wikipedia.org/wiki/Arginylglycylaspartic_acid

    Crystal structure of an extracellular segment of integrin alphaVbeta3 complexed with a cyclic peptide containing the arginyl-glycyl-aspartic acid (RGD) sequence. RGD is shown in maroon. CEND-1, also known as iRGD , is a cyclic peptide that homes to tumors via binding to integrin alpha V receptors. [ 22 ]

  4. iRGD - Wikipedia

    en.wikipedia.org/wiki/IRGD

    iRGD, also known as certepetide, is a 9-amino acid cyclic peptide (sequence: CRGDKGPDC) and a molecular mimicry agent that was originally identified in an in vivo screening of phage display libraries in tumor-bearing mice. [1]

  5. Diketopiperazine - Wikipedia

    en.wikipedia.org/wiki/Diketopiperazine

    DKP's are the smallest known class of cyclic peptide. [1] Despite their name, they are not ketones, but amides. Three regioisomers are possible, differing in the locations of the carbonyl groups. Retosiban [2] is a diketopiperazine being investigated as an oral drug. One isomer is an oxamide obtained from ethylenediamine.

  6. Cereulide - Wikipedia

    en.wikipedia.org/wiki/Cereulide

    Cereulide is a cyclic dodecadepsipeptide resembling valinomycin; it contains three repeats of four amino acids: D-Oxy-Leu—D-Ala—L-Oxy-Val—L-Val. It is produced by a dedicated non-ribosomal peptide synthesis (NRPS) system in B. cereus .

  7. α-Amanitin - Wikipedia

    en.wikipedia.org/wiki/Α-amanitin

    α-Amanitin (alpha-Amanitin) is a cyclic peptide of eight amino acids.It is possibly the most deadly of all the amatoxins, toxins found in several species of the mushroom genus Amanita, one being the death cap (Amanita phalloides) as well as the destroying angel, a complex of similar species, principally A. virosa and A. bisporigera.

  8. Phalloidin - Wikipedia

    en.wikipedia.org/wiki/Phalloidin

    Phalloidin was one of the first cyclic peptides to be discovered. It was isolated from the death cap mushroom and crystallized by Feodor Lynen and Ulrich Wieland [1] in 1937. [2] Its structure is unusual in that it contains a cysteine-tryptophan linkage to form a bicyclic heptapeptide. This linkage had not been characterized before and makes ...

  9. Contryphan - Wikipedia

    en.wikipedia.org/wiki/Contryphan

    The peptide backbone is depicted by a curved tube while the amino acid side-chains are represented by capped sticks. Carbon atoms are colored grey, nitrogen atoms blue, oxygen atoms red, and sulfur atoms yellow. [1].