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Luspatercept, sold under the brand name Reblozyl, is a medication used for the treatment of anemia in beta thalassemia and myelodysplastic syndromes. [ 5 ] The US Food and Drug Administration (FDA) considers it to be a first-in-class medication .
Luspatercept is a TGFβ ligand that acts to decrease SMAD2 and SMAD3 signaling involved in erythropoeisis and may be used in MDS with anemia that is not responsive to erythrocyte stimulating agents or mild MDS with ring sideroblasts. Luspatercept was shown to decrease the need for transfusions and this effect lasted for a median of 30.6 weeks.
Luspatercept - phase III: On 28 August 2023, BMS' drug Reblozyl has received FDA label expansion, making it a first-line treatment option for anemia in adults with low- to intermediate-risk myelodysplastic syndromes (MDS) who may need regular blood transfusions.
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Acceleron Pharma, Inc. is an American clinical stage biopharmaceutical company based in Cambridge, Massachusetts with a broad focus on developing medicines that regulate the transforming growth factor beta (TGF-β) superfamily of proteins, which play fundamental roles in the growth and repair of cells and tissues such as red blood cells, muscle, bone, and blood vessels.
The tattooed corpse of a woman was found bizarrely stuffed in a refrigerator dumped in some New Jersey woods — and cops say they need the public’s help identifying her.
Unfortunately, BYU spent most of the game Saturday knowing where Sanders was going. The Cougars blew out the Buffaloes 36-14, with Sanders finishing 16-of-23 for 208 yards, two touchdowns, two ...
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