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Diphenhydramine is a potent anticholinergic agent and potential deliriant in higher doses. This activity is responsible for the side effects of dry mouth and throat, increased heart rate, pupil dilation, urinary retention, constipation, and, at high doses, hallucinations or delirium.
British physiologist Sir Henry Hallett Dale (1875-1968) observed acetylcholine for causing blood vessel dilation and slowing down heart rate. In 1914, Dale noted that the physiological effect of acetylcholine resembled the stimulation of parasympathetic nervous system and hypothesized acetylcholine as the neurotransmitter.
Anticholinergics generally have antisialagogue effects (decreasing saliva production), and most produce some level of sedation, both being advantageous in surgical procedures. [ 8 ] [ 9 ] Until the beginning of the 20th century, anticholinergic drugs were widely used to treat psychiatric disorders.
Some drugs and medications affect heart rate, meaning you may have a lower maximum heart rate and target zone, says Dr. Steinbaum. “If you have a heart condition or take medication, ask your ...
Resting heart rate is related to a person’s cardiovascular training, says Dr. Joseph Ebinger, director of the coronary intensive care unit at the Smidt Heart Institute at Cedars-Sinai Medical ...
Certain medications and medical conditions may also affect your heart rate. Always be aware of the possible side effects of prescription and over-the-counter medicines, as some may cause your ...
Diphenhydramine has a common side effect of drowsiness or sleepiness. [12] Because of these sedative properties, Benadryl is often used as a sleep aid in people with insomnia . A study published in the American Journal of Geriatric Psychiatry discovered that approximately one in three adults between the ages of 65 and 80 occasionally use over ...
If you've ever popped a Benadryl or two to sleep through a long flight (or even just a regular night), you can pretty much count yourself among the majority of the population.