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The Enzyme Commission refers to this family as SARS coronavirus main proteinase (M pro; EC 3.4.22.69). The 3CL protease corresponds to coronavirus nonstructural protein 5 (nsp5). The "3C" in the common name refers to the 3C protease (3C pro ) which is a homologous protease found in picornaviruses .
SARS-CoV-2 is the seventh known coronavirus to infect people, after 229E, NL63, OC43, HKU1, MERS-CoV, and the original SARS-CoV. [105] Like the SARS-related coronavirus implicated in the 2003 SARS outbreak, SARS‑CoV‑2 is a member of the subgenus Sarbecovirus (beta-CoV lineage B). [106] [107] Coronaviruses undergo frequent recombination. [108]
COVID-19 testing involves analyzing samples to assess the current or past presence of SARS-CoV-2, the virus that cases COVID-19 and is responsible for the COVID-19 pandemic. The two main types of tests detect either the presence of the virus or antibodies produced in response to infection.
Severe acute respiratory syndrome coronavirus (SARS-CoV-1) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) The structures of HCoV-HKU1 spike (S) and hemagglutinin esterase (HE) proteins have been resolved by Cryo-EM in 2016 and 2020, respectively. The S protein ( ) has been noted for its large size. [13]
COVID-19 is the deadliest pandemic in US history; [360] it was the third-leading cause of death in the US in 2020, behind heart disease and cancer. [361] From 2019 to 2020, US life expectancy dropped by 3 years for Hispanic Americans, 2.9 years for African Americans, and 1.2 years for white Americans. [362]
In 2019, there was a "healthspan-lifespan gap" of 9.6 years globally, a 13% increase from 8.5 years in 2019, Mayo Clinic researchers found. 'I'm A Doctor — Here's The Wellness Routine I Follow ...
The COVID-19 virus has not been detected in drinking water. [82] Conventional water treatment (filtration and disinfection) inactivates or removes the virus. [82] COVID-19 virus RNA is found in untreated wastewater, [82] [22] [83] [a] but there is no evidence of COVID-19 transmission through exposure to untreated wastewater or sewerage systems ...
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