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For example, carbonic anhydrase produces acid in the stomach lining. In the kidney, the control of bicarbonate ions influences the water content of the cell. The control of bicarbonate ions also influences the water content in the eyes. Inhibitors of carbonic anhydrase are used to treat glaucoma, the excessive build-up of water in the eyes.
Other forms of carbonic anhydrase enzyme are not present in the plasma, restricting the equilibrium reaction of CO 2 + H 2 O = H 2 CO 3 = H+ HCO − 3. CO 2 in the plasma diffuses into the Red Blood Cell. CA is present within the Red Blood Cell, facilitating the conversion of CO 2 to HCO − 3. HCO − 3 so produced is transferred by the HCO −
The reaction catalyzed by CA1 is the same as other carbonic anhydrase family proteins: + (in tissues - high CO 2 concentration) [9]. The CA1-catalyzed reaction has a relatively low reaction affinity (Km) of 4.0 mM for CO 2, [7] [10] turnover number (Kcat) of 2 × 10 5 s −1, and catalytic efficiency (Kcat/Km) of 5 × 10 7 M −1 s −1 comparing to other isozymes of the α-CA family of ...
770 12348 Ensembl ENSG00000063180 ENSMUSG00000003273 UniProt O75493 O70354 RefSeq (mRNA) NM_001217 NM_009800 NM_001368349 RefSeq (protein) NP_001208 NP_033930 NP_001355278 Location (UCSC) Chr 19: 48.64 – 48.65 Mb Chr 7: 45.35 – 45.35 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Carbonic anhydrase-related protein 11 is a protein that in humans is encoded by the CA11 gene ...
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in various biological processes, including respiration, calcification , acid-base balance, bone resorption , and the formation of aqueous humor, cerebrospinal fluid , saliva, and gastric acid.
The bicarbonate buffer system is an acid-base homeostatic mechanism involving the balance of carbonic acid (H 2 CO 3), bicarbonate ion (HCO − 3), and carbon dioxide (CO 2) in order to maintain pH in the blood and duodenum, among other tissues, to support proper metabolic function. [1] Catalyzed by carbonic anhydrase, carbon dioxide (CO 2 ...
Carbonic anhydrases (CAs) are a family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid.
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