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The ESR is decreased in polycythemia, hyperviscosity, sickle cell anemia, leukemia, chronic fatigue syndrome, [4] low plasma protein (due to liver or kidney disease) and congestive heart failure. Although increases in immunoglobulins usually increase the ESR, very high levels can reduce it again due to hyperviscosity of the plasma. [5]
CRP is produced by the liver in response to an injury or infection, and people with polymyalgia rheumatica usually have high levels. [17] [18] However, like the ESR, this test is also not very specific. [citation needed] Polymyalgia rheumatica is sometimes associated with temporal arteritis, a condition requiring more aggressive therapy.
In contrast, C-reactive protein (with a half-life of 6–8 hours) rises rapidly and can quickly return to within the normal range if treatment is employed. For example, in active systemic lupus erythematosus, one may find a raised ESR but normal C-reactive protein. [citation needed] They may also indicate liver failure. [11]
acute phase reactants: 1 point for elevated erythrocyte sedimentation rate, ESR, or elevated CRP value (c-reactive protein) duration of arthritis : 1 point for symptoms lasting six weeks or longer The new criteria accommodate to the growing understanding of RA and the improvements in diagnosing RA and disease treatment.
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Patients with UCTD usually have positive ANA (antinuclear antibody), and raised ESR (erythrocyte sedimentation rate) values, without typical autoantibody specificities. [14] Some 20% of the general population, [ 15 ] and up to 15% of completely healthy people, [ 16 ] test positive for ANA, but nonetheless this is regarded by some as almost ...
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