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Brimonidine is an α 2 agonist medication used to treat open-angle glaucoma, ocular hypertension, and rosacea. [4] [5] In rosacea it improves the redness. [5] It is used as eye drops or applied to the skin. [4] [5] It is also available in the fixed-dose combination medication brimonidine/timolol along with timolol maleate. [6]
Brinzolamide works by blocking an enzyme called carbonic anhydrase, which produces bicarbonate needed for the production of the aqueous humour, while brimonidine tartrate blocks another enzyme known as adenylate cyclase, which is also involved in the production of the aqueous humour. [4]
Brimonidine/timolol, sold under the brand name Combigan among others, is a fixed-dose combination medication eye drop used for the treatment of glaucoma. [1] It is a combination of brimonidine (an α 2 adrenergic agonist ) and timolol (a β adrenergic blocker ).
It's particularly effective for older women concerned with damaging delicate under-eye areas and causing fine lines by scrubbing away mascara and eyeliner. It's also safe for all skin types.
“Pregnant women and women trying to conceive should be taking prenatal vitamins. The most important reason is the folate supplementation,” says s Shanna Levine, M.D., primary care physician at ...
For years, doctors used antibiotics, topical medications, injections of cortisone and surgery. “But as it gets more intense, it becomes a major problem,” he says. Courtesy of Chaquira Andrade
Use is not recommended in those with asthma, uncompensated heart failure, or chronic obstructive pulmonary disease (COPD). [3] It is unclear if use during pregnancy is safe for the fetus. [6] Timolol is a non-selective beta blocker. [3] Timolol was patented in 1968, and came into medical use in 1978. [7]
While definitive sites of metabolism have not been firmly established, there are several metabolites worthy of note. N-Desethylbrinzolamide is an active metabolite of the parent compound, and thus exhibits carbonic anhydrase inhibitory activity (largely carbonic anhydrase-I, when in the presence of Brinzolamide) and also accumulates in the erythrocytes.