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  2. Antimicrobial - Wikipedia

    en.wikipedia.org/wiki/Antimicrobial

    An antimicrobial is an agent that kills microorganisms (microbicide) or stops their growth (bacteriostatic agent). [1] Antimicrobial medicines can be grouped according to the microorganisms they act primarily against. For example, antibiotics are used against bacteria, and antifungals are used against fungi. They can also be classified ...

  3. Multidrug-resistant Gram-negative bacteria - Wikipedia

    en.wikipedia.org/wiki/Multidrug-resistant_gram...

    A review of investigational antibiotics shows that several new agents will become available in the coming years, even though the pace of antimicrobial research has proven far too slow. Overuse of antimicrobial agents and problems with infection control practices have led to the development of multidrug-resistant gram-negative bacterial infections.

  4. Antimicrobial stewardship - Wikipedia

    en.wikipedia.org/wiki/Antimicrobial_stewardship

    Every time an antimicrobial agent is used, it applies selection evolutionary pressure to microbial populations which can result in disruption to the normal microbiome as well as resistance to that agent, and even cross-resistance to other agents. Resistance can then spread to other microbes and to other host organisms.

  5. Antimicrobial pharmacodynamics - Wikipedia

    en.wikipedia.org/wiki/Antimicrobial_pharmacodynamics

    Antimicrobial pharmacodynamics is the relationship between the concentration of an antibiotic and its ability to inhibit vital processes of endo- or ectoparasites and microbial organisms. [1] This branch of pharmacodynamics relates the concentration of an anti-infective agent to its effect, specifically to its antimicrobial effect.

  6. Antimicrobial resistance - Wikipedia

    en.wikipedia.org/wiki/Antimicrobial_resistance

    Over time, most of the strains of bacteria and infections present will be the type resistant to the antimicrobial agent being used to treat them, making this agent now ineffective to defeat most microbes. With the increased use of antimicrobial agents, there is a speeding up of this natural process. [29]

  7. Antimicrobial spectrum - Wikipedia

    en.wikipedia.org/wiki/Antimicrobial_spectrum

    The antimicrobial spectrum of an antibiotic can be determined by testing its antimicrobial activity against a wide range of microbes in vitro. Nonetheless, the range of microorganisms which an antibiotic can kill or inhibit in vivo may not always be the same as the antimicrobial spectrum based on data collected in vitro. [2] [5]

  8. List of antibiotic-resistant bacteria - Wikipedia

    en.wikipedia.org/wiki/List_of_antibiotic...

    The evolution of bacteria on a "Mega-Plate" petri dish A list of antibiotic resistant bacteria is provided below. These bacteria have shown antibiotic resistance (or antimicrobial resistance). Gram positive Clostridioides difficile Clostridioides difficile is a nosocomial pathogen that causes diarrheal disease worldwide. Diarrhea caused by C. difficile can be life-threatening. Infections are ...

  9. Discovery and development of cephalosporins - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    An important structural change in the development of second generation cephalosporins was the introduction of an α-iminomethoxy group to the C-7 side chain. This gave an increased resistance to β-lactamases due to stereochemical blocking of the beta-lactam ring. Cefuroxime was the first cephalosporin to incorporate this side chain.