Search results
Results from the WOW.Com Content Network
Hypoprothrombinemia can be the result of a genetic defect, may be acquired as the result of another disease process, or may be an adverse effect of medication.For example, 5-10% of patients with systemic lupus erythematosus exhibit acquired hypoprothrombinemia due to the presence of autoantibodies which bind to prothrombin and remove it from the bloodstream (lupus anticoagulant ...
Main page; Contents; Current events; Random article; About Wikipedia; Contact us; Pages for logged out editors learn more
Colucci, Mario; Binetti, Bianca M.; Tripodi, Armando; Chantarangkul, Veena; Semeraro, Nicola (March 15, 2004). "Hyperprothrombinemia associated with prothrombin ...
2147 14061 Ensembl ENSG00000180210 ENSMUSG00000027249 UniProt P00734 P19221 RefSeq (mRNA) NM_000506 NM_001311257 NM_010168 RefSeq (protein) NP_000497 NP_034298 Location (UCSC) Chr 11: 46.72 – 46.74 Mb Chr 2: 91.46 – 91.47 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Role of thrombin in the blood coagulation cascade Prothrombin (coagulation factor II) is encoded in the human by ...
Several cephalosporins are associated with hypoprothrombinemia and a disulfiram-like reaction with ethanol. [15] [16] These include latamoxef , cefmenoxime, cefoperazone, cefamandole, cefmetazole, and cefotetan.
As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase)(vitamin K supplement is recommended during therapy) and a reaction with ethanol similar to that produced by disulfiram (Antabuse), due to inhibition of aldehyde dehydrogenase.
Factor X deficiency (X as Roman numeral ten) is a bleeding disorder characterized by a lack in the production of factor X (FX), an enzyme protein that causes blood to clot in the coagulation cascade.
Platelet storage pool deficiency is a family of clotting disorders characterized by deficient granules in platelets.Individuals with these disorders have too few or abnormally functioning alpha granules, delta granules, or both alpha and delta granules and are therefore unable to form effective clots, which leads to prolonged bleeding.