Search results
Results from the WOW.Com Content Network
Scorpion toxins are proteins found in the venom of scorpions.Their toxic effect may be mammal- or insect-specific and acts by binding with varying degrees of specificity to members of the Voltage-gated ion channel superfamily; specifically, voltage-gated sodium channels, voltage-gated potassium channels, [3] and Transient Receptor Potential (TRP) channels.
Cn2 is a neurotoxin named after and derived from the Centruroides noxius scorpion, which originates from and is endemic in the state of Nayarit, Western Mexico. [1] This scorpion produces a venom in which the Cn2 toxin is the most abundant component; it comprises approximately 6.8% of the scorpion venom.
The deathstalker is one of the most dangerous species of scorpions. [10] [11] Its venom is a powerful mixture of neurotoxins, with a low lethal dose. [12]While a sting from this scorpion is extraordinarily painful, it normally would not kill a healthy adult human.
Tityustoxin-1, TsTX-I is the most toxic protein among the neurotoxins in this venom, with an intravenous and intracisternal LD 50 (mouse) of 76 ± 9 and 1.1 ± 0.3 μg/kg, respectively. The identification of TsTX-I as a potent component of T. serrulatus venom characterized it as the major and main neurotoxin from this venom. [ 1 ]
A scorpion sting is an injury caused by the stinger of a scorpion resulting in the medical condition known as scorpionism, which may vary in severity. The anatomical part of the scorpion that delivers the sting is called a "telson". In typical cases, scorpion stings usually result in pain, paresthesia, and variable swelling.
CboK7, also known as α-KTx 2.24, is a toxin produced by a species of scorpion, Centruroides bonito. It blocks voltage-gated K + channels , with the highest affinity for K v 1.2 channels. Etymology
ImKTX58 (also known as kappa-Buthitoxin-Im1a) is a peptide toxin from the venom of the scorpion species Isometrus maculatus (also known as the lesser brown scorpion). It is known for its selective inhibition of Kv1.3 channels , on which it acts as a pore-blocker.
NTX accounts for only about 1% of the scorpion venom. [7] NTX is one of the best-studied toxic peptides from scorpion venoms. [6] It was the second purified toxin obtained from the genus Centruroides after neurotoxin II [8] and the first short peptide from scorpion venom to be reported in the literature. [9]