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Homeobox genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure that binds DNA to regulate expression of target genes. [ 3 ] [ 4 ] [ 2 ] Homeodomain proteins regulate gene expression and cell differentiation during early embryonic development, thus mutations in homeobox genes can ...
The homeodomain is a 60-amino-acid-long DNA-binding domain (encoded by its corresponding 180-base-pair DNA sequence, the homeobox). This amino acid sequence folds into a "helix-turn-helix" (i.e. homeodomain fold) motif that is stabilized by a third helix.
Retinal homeobox protein Rx also known as retina and anterior neural fold homeobox is a protein that in humans is encoded by the RAX gene. [5] The RAX gene is located on chromosome 18 in humans, mice, and rats.
10481 15408 Ensembl ENSG00000159184 ENSMUSG00000049604 UniProt Q92826 P70321 RefSeq (mRNA) NM_006361 NM_008267 RefSeq (protein) NP_006352 NP_032293 Location (UCSC) Chr 17: 48.72 – 48.73 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-B13 is a protein that in humans is encoded by the HOXB13 gene. Function This gene encodes a transcription factor that belongs ...
15394 Ensembl ENSG00000105991 ENSMUSG00000029844 UniProt P49639 P09022 RefSeq (mRNA) NM_153620 NM_005522 NM_010449 NM_001311118 RefSeq (protein) NP_005513 NP_705873 n/a Location (UCSC) Chr 7: 27.09 – 27.1 Mb Chr 6: 52.13 – 52.14 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-A1 is a protein that in humans is encoded by the HOXA1 gene. Gene Two transcript ...
18091 Ensembl ENSG00000183072 ENSMUSG00000015579 UniProt P52952 P42582 RefSeq (mRNA) NM_004387 NM_001166175 NM_001166176 NM_008700 RefSeq (protein) NP_001159647 NP_001159648 NP_004378 NP_032726 Location (UCSC) Chr 5: 173.23 – 173.24 Mb Chr 17: 27.06 – 27.06 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Nkx-2.5 is a protein that in humans is encoded by the NKX2 ...
This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber's congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full ...
15433 Ensembl ENSG00000128714 ENSMUSG00000001819 UniProt P35453 P70217 RefSeq (mRNA) NM_000523 NM_008275 RefSeq (protein) NP_000514 NP_032301 Location (UCSC) Chr 2: 176.09 – 176.1 Mb Chr 2: 74.5 – 74.5 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-D13 is a protein that in humans is encoded by the HOXD13 gene. This gene belongs to the homeobox family of ...