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Homeobox genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure that binds DNA to regulate expression of target genes. [ 3 ] [ 4 ] [ 2 ] Homeodomain proteins regulate gene expression and cell differentiation during early embryonic development, thus mutations in homeobox genes can ...
Retinal homeobox protein Rx also known as retina and anterior neural fold homeobox is a protein that in humans is encoded by the RAX gene. [5] The RAX gene is located on chromosome 18 in humans, mice, and rats.
The protein product of each Hox gene is a transcription factor. Each Hox gene contains a well-conserved DNA sequence known as the homeobox, of which the term "Hox" was originally a contraction. However, in current usage the term Hox is no longer equivalent to homeobox, because Hox genes are not the only genes to possess a homeobox sequence; for ...
15394 Ensembl ENSG00000105991 ENSMUSG00000029844 UniProt P49639 P09022 RefSeq (mRNA) NM_153620 NM_005522 NM_010449 NM_001311118 RefSeq (protein) NP_005513 NP_705873 n/a Location (UCSC) Chr 7: 27.09 – 27.1 Mb Chr 6: 52.13 – 52.14 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-A1 is a protein that in humans is encoded by the HOXA1 gene. Gene Two transcript ...
This gene and other HOXB genes form a gene cluster on chromosome 17 in the 17q21.32 region. [6] Men who inherit a rare (<0.1% in a selected group of patients without clinical signs of prostate cancer ) genetic variant in HOXB13 (G84E or rs138213197) have a 10-20-fold increased risk of prostate cancer.
15405 Ensembl ENSG00000078399 ENSMUSG00000038227 UniProt P31269 P09631 RefSeq (mRNA) NM_152739 NM_002142 NM_001277238 NM_010456 RefSeq (protein) NP_689952 NP_001264167 NP_034586 Location (UCSC) Chr 7: 27.16 – 27.18 Mb Chr 6: 52.2 – 52.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-A9 is a protein that in humans is encoded by the HOXA9 gene. In vertebrates ...
Gene editing may one day cure the oral herpes virus. Here's why that virus is tough to tackle and how to prevent and minimize symptoms until a cure arrives.
18091 Ensembl ENSG00000183072 ENSMUSG00000015579 UniProt P52952 P42582 RefSeq (mRNA) NM_004387 NM_001166175 NM_001166176 NM_008700 RefSeq (protein) NP_001159647 NP_001159648 NP_004378 NP_032726 Location (UCSC) Chr 5: 173.23 – 173.24 Mb Chr 17: 27.06 – 27.06 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Nkx-2.5 is a protein that in humans is encoded by the NKX2 ...