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Zoliflodacin (development codes AZD0914 and ETX0914) is an experimental antibiotic that is being studied for the treatment of infection with Neisseria gonorrhoeae (). [1] It has a novel mechanism of action which involves inhibition of bacterial type II topoisomerases. [2]
The antibiotic, which would be the first new gonorrhea treatment approved in decades, could make it to market by 2025. ... with cases of highly drug-resistant gonorrhea reported in multiple ...
Gonorrhea can be prevented with the use of condoms, having sex with only one person who is uninfected, and by not having sex. [1] [3] Treatment is usually with ceftriaxone by injection and azithromycin by mouth. [4] [5] Resistance has developed to many previously used antibiotics and higher doses of ceftriaxone are occasionally required.
Each drug should be administered as a single dose, with the gentamicin entering intramuscularly at a concentration of 240 mg, along with 2 g of azithromycin taken orally. [79] If an individual is not allergic to cephalosporins but ceftriaxone is unavailable, an alternative treatment is a single dose of 800 mg cefixime consumed orally. [79]
A study out of the University of York shows that carbon monoxide-releasing molecules could be the key to developing a new antibiotic to treat gonorrhea.
Adalja says that everyone should be concerned about acquiring drug-resistant forms of gonorrhea because it is more difficult and complicated to treat. He adds: “It is likely that rates of ...
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