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  2. Apixaban - Wikipedia

    en.wikipedia.org/wiki/Apixaban

    Apixaban is recommended by the National Institute for Health and Clinical Excellence for the prevention of stroke and systemic embolism in people with non-valvular atrial fibrillation and at least one of the following risk factors: prior stroke or transient ischemic attack, age 75 years or older, diabetes, or symptomatic heart failure.

  3. Discovery and development of direct Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    The p-methoxy group of apixaban connects to S1 pocket of FXa but does not appear to have any interaction with any residues in this region of FXa. The pyrazole N-2 nitrogen atom of apixaban interacts with Gln-192 and the carbonyl oxygen interacts with Gly-216. The phenyl lactam group of apixaban is positioned between Tyr-99 and Phe-174 and due ...

  4. WHO Model List of Essential Medicines - Wikipedia

    en.wikipedia.org/wiki/WHO_Model_List_of...

    This list contains 1200 recommendations for 591 drugs and 103 therapeutic equivalents. [20] A separate list for children up to 12 years of age, known as the WHO Model List of Essential Medicines for Children (EMLc), was created in 2007 and is in its 9th edition.

  5. Her daughter's suicide shocked the community. Now, she's ...

    www.aol.com/her-daughters-suicide-shocked...

    This mom lost her 15-year-old daughter to suicide. She wants people to know that suicide and depression aren't linear.

  6. Hegseth says gay soldiers should serve in the military in ...

    www.aol.com/hegseth-says-gay-soldiers-serve...

    Donald Trump’s pick for defense secretary, Pete Hegseth, said gay people should be able to serve in the US military in an apparent shift from his previous stance on the issue.

  7. Teenager accused in Wisconsin school shooting had a ...

    www.aol.com/teenager-accused-wisconsin-school...

    MADISON, Wis. — A 15-year-old girl who police say killed two people and wounded multiple others at a private Christian school in Wisconsin endured what appeared to be a tumultuous home life ...

  8. Ciraparantag - Wikipedia

    en.wikipedia.org/wiki/Ciraparantag

    Ciraparantag (aripazine) is a drug under investigation as an antidote for a number of anticoagulant (anti-blood clotting) drugs, including factor Xa inhibitors (rivaroxaban, apixaban and edoxaban), dabigatran, and heparins (including fondaparinux, low molecular weight heparins (LMWH), and unfractionated heparin). [1] [2]

  9. Anticoagulant - Wikipedia

    en.wikipedia.org/wiki/Anticoagulant

    An anticoagulant, commonly known as a blood thinner, is a chemical substance that prevents or reduces the coagulation of blood, prolonging the clotting time. [1] Some occur naturally in blood-eating animals, such as leeches and mosquitoes, which help keep the bite area unclotted long enough for the animal to obtain blood.