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Side effects of estradiol valerate include breast tenderness, breast enlargement, nausea, headache, and fluid retention. [15] [13] [14] Estradiol valerate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. [5] [4] [16] It is an estrogen ester and a prodrug of estradiol in the body.
Estradiol, mainly as esters including estradiol valerate, estradiol cypionate, and estradiol enanthate, is also the exclusive estrogen used in combined injectable contraceptives. [ 6 ] As of 2021, more than 95% of prescriptions are for combined hormonal birth control forms containing the synthetic estrogen ethinylestradiol (EE). [ 7 ]
Estradiol valerate/cyproterone acetate (EV/CPA), sold under the brand names Climen and Femilar among others, is a combination product of estradiol valerate (EV), an estrogen, and cyproterone acetate (CPA), a progestogen, which is used in menopausal hormone therapy and as a birth control pill to prevent pregnancy. [1] It is taken by mouth. [1]
Estradiol valerate: 10–40 mg 1x/1–2 weeks Estradiol undecylate: 100 mg 1x/4 weeks Polyestradiol phosphate: Alone: 160–320 mg 1x/4 weeks With oral EE: 40–80 mg 1x/4 weeks Estrone: 2–4 mg 2–3x/week IV injection: Fosfestrol: 300–1200 mg 1–7x/week Estramustine phosphate: 240–450 mg/day Note: Dosages are not necessarily equivalent ...
Estradiol (E2) is a medication and naturally occurring steroid hormone. [11] [12] [13] It is an estrogen and is used mainly in menopausal hormone therapy and to treat low sex hormone levels in women.
Estradiol valerate 2.5 to 5 mg + norethisterone enantate 50 to 80 mg in an oil solution [15] [16] Estradiol valerate 10 mg + hydroxyprogesterone caproate 500 mg in an oil solution [15] Estradiol cypionate 2.5 to 10 mg + medroxyprogesterone acetate 12.5 to 50 mg in a microcrystalline aqueous suspension [15] [16]
Estradiol valerate/prasterone enanthate (EV/DHEA-E), sold under the brand name Gynodian Depot among others, is an injectable combination medication of estradiol valerate (EV), an estrogen, and prasterone enanthate (DHEA-E), an androgen, estrogen, and neurosteroid, which is used in menopausal hormone therapy for women.
Estradiol acetate is a synthetic estrane steroid and the C3 acetate ester of estradiol. [3] It is also known as estradiol 3-acetate or as estra-1,3,5(10)-triene-3,17β-diol 3-acetate. [3] Another common ester of estradiol in use for oral administration is estradiol valerate, which is a C17β ester of estradiol. [8] [23]
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