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The role of clozapine in treatment-resistant schizophrenia was established by a 1988 landmark multicenter double blind study [39] in which clozapine (up to 900 mg/d) showed marked benefits compared to chlorpromazine (up to 1800 mg/d) in a group of patients with protracted psychosis who had already shown an inadequate response to at least three ...
Clozapine is an effective treatment for those who respond poorly to other drugs ("treatment-resistant" or "refractory" schizophrenia), [94] but it has the potentially serious side effect of agranulocytosis (lowered white blood cell count) in less than 4% of people.
Antipsychotics by class Generic name Brand names Chemical class ATC code ... Clozapine: Clozaril: tricyclic dibenzodiazepine: N05AH02 Iloperidone: Fanapt: benzisoxazole:
Clozapine (Clozaril), an atypical antipsychotic, fell out of favor due to concerns over drug-induced agranulocytosis. Following research indicating its effectiveness in treatment-resistant schizophrenia and the development of an adverse event monitoring system, clozapine re-emerged as a viable antipsychotic.
The estimated yearly cost for Cobenfy is $22,500 compared to $540 for a generic antipsychotic. Krystal and others worry that insurers will require people to try cheaper drugs first before covering Cobenfy. One cheaper generic called clozapine is widely considered one of the best treatments for schizophrenia, Krystal said.
Serax – anti-anxiety medication of the benzodiazepine class, often used to help during detoxification from alcohol or other addictive substances; Serentil (mesoridazine) – an antipsychotic drug used in the treatment of schizophrenia [1]
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