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The long-term safety and effectiveness of modafinil have not been conclusively established. [100] The FDA does not endorse modafinil for children's medical conditions due to an increased risk of rare but serious dermatological toxicity, manifested as Stevens–Johnson syndrome which is a type of severe skin reaction.
Modafinil appeared to be more potent than adrafinil in animal studies, and was selected for further clinical development, with both adrafinil and modafinil eventually reaching the market. [18] Modafinil was first approved in France in 1994, and then in the United States in 1998. [19] Lafon was acquired by Cephalon in 2001. [20]
[2] [8] Unlike modafinil, flmodafinil does not induce cytochrome P450 enzymes. [2] Chemically, flmodafinil is an enantiopure derivative of modafinil and is also known as bisfluoromodafinil (it is the (R)-bis(4-fluoro) phenyl ring-substituted derivative of modafinil). [2] [8] Flmodafinil was developed by NLS Pharma. [3]
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Like modafinil, armodafinil is an inhibitor and/or inducer of certain cytochrome P450 enzymes. [7] [26] It moderately induces CYP3A4 and moderately inhibits CYP2C19. [7] [26] In contrast to modafinil however, armodafinil does not induce CYP1A2. [7] [26]
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Long-term safety evidence is typically unavailable for many nootropic compounds. ... (armodafinil and modafinil) ... This page was last edited on 19 November 2024, ...
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